Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
drd3_human 392 8.52x52 H8 K => SerfsTer? frameshift 8.64e-06 1 115746 0 None None
drd3_human 299 ICL3 R => Ter stop gained 2.471e-05 3 121412 0 None None
drd3_human 234 ICL3 V => GlnfsTer12 frameshift 8.242e-06 1 121334 0 None None
drd3_human 226 5.76x76 TM5 R => Ter stop gained 8.239e-06 1 121370 0 None None
drd3_human 396 8.56x56 H8 K => Q missense 8.728e-06 1 114574 0 0.0 0.984
drd3_human 395 8.55x55 H8 L => F missense 8.702e-06 1 114922 0 0.05 0.978
drd3_human 391 8.51x51 H8 R => Q missense 7.719e-05 9 116598 0 0.0 1.0 GP (contact)
drd3_human 388 8.48x48 H8 I => T missense 8.428e-06 1 118654 0 0.37 0.003 GP (contact)
drd3_human 378 7.48x48 TM7 L => P missense 8.269e-06 1 120938 0 0.0 0.997
drd3_human 377 7.47x47 TM7 A => V missense 8.265e-06 1 120998 0 0.0 0.999
drd3_human 377 7.47x47 TM7 A => T missense 1.653e-05 2 121008 0 0.0 0.999
drd3_human 375 7.45x45 TM7 N => D missense 8.259e-06 1 121078 0 0.0 0.999
drd3_human 374 7.44x43 TM7 V => M missense 4.129e-05 5 121094 0 0.02 0.278 SodiumPocket MicroSwitch
drd3_human 374 7.44x43 TM7 V => L missense 8.258e-06 1 121094 0 0.09 0.267 SodiumPocket MicroSwitch
drd3_human 372 7.42x41 TM7 G => D missense 8.255e-06 1 121146 0 0.0 1.0 LB (Van der Waals)
drd3_human 368 7.38x37 TM7 T => M missense 1.651e-05 2 121160 0 0.08 0.979
drd3_human 362 7.32x31 TM7 P => S missense 8.265e-06 1 120998 0 0.03 0.984
drd3_human 360 ECL3 V => A missense 8.272e-06 1 120894 0 0.06 0.769
drd3_human 360 ECL3 V => M missense 1.655e-05 2 120858 0 0.0 0.958
drd3_human 353 6.59x59 TM6 T => I missense 8.347e-06 1 119798 0 0.12 0.816
drd3_human 348 6.54x54 TM6 T => I missense 8.439e-06 1 118494 0 0.26 0.017
drd3_human 346 6.52x52 TM6 F => L missense 3.398e-05 4 117706 0 0.0 0.985 LB (hydrophobic, Van der Waals, aromatic (edge-to-face), polar (hydrogen bond))
drd3_human 340 6.46x46 TM6 V => F missense 4.329e-05 5 115494 0 0.31 0.771
drd3_human 326 6.32x32 TM6 K => E missense 8.245e-06 1 121282 0 0.0 0.999 GP (contact)
drd3_human 323 6.29x29 TM6 R => Q missense 1.648e-05 2 121338 0 0.01 0.969 GP (contact)
drd3_human 323 6.29x29 TM6 R => P missense 8.241e-06 1 121338 0 0.0 0.994 GP (contact)
drd3_human 322 6.28x28 TM6 L => V missense 8.239e-06 1 121370 0 0.27 0.734 GP (contact)
drd3_human 318 6.24x24 TM6 R => Q missense 8.238e-06 1 121386 0 0.04 0.94
drd3_human 315 ICL3 L => P missense 8.237e-06 1 121406 0 0.23 0.02
drd3_human 314 ICL3 P => L missense 5.766e-05 7 121406 0 0.18 0.096
drd3_human 314 ICL3 P => T missense 3.295e-05 4 121408 0 0.57 0.005
drd3_human 305 ICL3 R => S missense 8.236e-06 1 121412 0 0.07 0.46
drd3_human 299 ICL3 R => Q missense 8.236e-06 1 121412 0 0.8 0.005
drd3_human 291 ICL3 A => E missense 1.647e-05 2 121412 0 0.62 0.313
drd3_human 291 ICL3 A => V missense 3.295e-05 4 121412 0 0.26 0.27
drd3_human 291 ICL3 A => T missense 1.647e-05 2 121412 0 0.48 0.037
drd3_human 290 ICL3 I => M missense 8.236e-06 1 121412 0 0.42 0.001
drd3_human 290 ICL3 I => T missense 8.236e-06 1 121412 0 0.45 0.023
drd3_human 285 ICL3 S => F missense 8.236e-06 1 121412 0 0.01 0.789 PTM (Phosphorylation)
drd3_human 283 ICL3 R => Q missense 0.00014 17 121412 0 0.23 0.007
drd3_human 281 ICL3 K => E missense 8.236e-06 1 121412 0 0.27 0.003
drd3_human 275 ICL3 E => A missense 8.236e-06 1 121412 0 0.47 0.012
drd3_human 274 ICL3 G => E missense 2.471e-05 3 121412 0 0.17 0.043
drd3_human 266 ICL3 G => R missense 8.237e-06 1 121410 0 0.67 0.006
drd3_human 262 ICL3 T => A missense 2.471e-05 3 121406 0 0.7 0.01
drd3_human 254 ICL3 R => H missense 8.239e-06 1 121368 0 0.1 0.026
drd3_human 254 ICL3 R => C missense 4.12e-05 5 121372 0 0.05 0.443
drd3_human 247 ICL3 P => L missense 2.476e-05 3 121180 0 0.12 0.026
drd3_human 240 ICL3 Q => H missense 1.649e-05 2 121298 0 0.2 0.017
drd3_human 240 ICL3 Q => E missense 8.246e-06 1 121274 0 0.86 0.138
drd3_human 239 ICL3 P => L missense 8.245e-06 1 121284 0 0.09 0.026
drd3_human 237 ICL3 G => D missense 8.246e-06 1 121272 0 0.33 0.057
drd3_human 231 ICL3 C => Y missense 8.241e-06 1 121344 0 0.05 0.601
drd3_human 231 ICL3 C => S missense 0.0004944 60 121350 0 0.68 0.059
drd3_human 230 ICL3 Q => P missense 8.24e-06 1 121352 0 0.18 0.499
drd3_human 226 5.76x76 TM5 R => Q missense 8.239e-06 1 121370 0 0.23 0.924
drd3_human 223 5.73x73 TM5 I => T missense 8.238e-06 1 121394 0 0.49 0.026
drd3_human 220 5.70x70 TM5 R => Q missense 1.647e-05 2 121406 0 0.07 0.005
drd3_human 220 5.70x70 TM5 R => W missense 8.237e-06 1 121406 0 0.0 0.732
drd3_human 214 5.64x64 TM5 V => A missense 6.589e-05 8 121408 0 0.26 0.079 GP (contact)
drd3_human 210 5.60x60 TM5 R => G missense 8.236e-06 1 121412 0 0.1 0.949
drd3_human 207 5.57x57 TM5 V => A missense 8.237e-06 1 121406 0 0.0 0.717
drd3_human 198 5.48x48 TM5 Y => C missense 8.238e-06 1 121386 0 0.0 0.988
drd3_human 190 5.40x41 TM5 I => V missense 8.25e-06 1 121206 0 0.82 0.009
drd3_human 178 ECL2 P => T missense 8.312e-06 1 120304 0 0.03 0.974
drd3_human 170 4.62x63 TM4 F => L missense 1.649e-05 2 121316 0 0.05 0.053
drd3_human 157 4.49x49 TM4 V => I missense 2.472e-05 3 121382 0 0.01 0.343
drd3_human 155 4.47x47 TM4 T => M missense 1.648e-05 2 121382 0 0.0 0.813
drd3_human 151 4.43x43 TM4 A => T missense 0.0001318 16 121376 0 0.98 0.003
drd3_human 149 4.41x41 TM4 R => H missense 1.648e-05 2 121372 0 0.0 0.04
drd3_human 149 4.41x41 TM4 R => C missense 8.239e-06 1 121370 0 0.0 0.935
drd3_human 148 4.40x40 TM4 R => Q missense 4.12e-05 5 121368 0 0.05 0.31
drd3_human 148 4.40x40 TM4 R => W missense 8.239e-05 10 121370 0 0.0 0.966
drd3_human 142 34.57x57 ICL2 T => M missense 5.769e-05 7 121334 0 0.0 0.952 GP (contact)
drd3_human 136 34.51x51 ICL2 V => I missense 0.0006021 73 121250 1 0.16 0.399 GP (contact)
drd3_human 135 34.50x50 ICL2 P => H missense 8.248e-06 1 121246 0 0.0 1.0 GP (contact)
drd3_human 133 3.55x55 TM3 V => I missense 8.252e-06 1 121190 0 0.04 0.47 GP (contact)
drd3_human 124 3.46x46 TM3 I => T missense 8.24e-06 1 121360 0 0.0 1.0
drd3_human 116 3.38x38 TM3 A => D missense 1.648e-05 2 121388 0 0.0 1.0
drd3_human 102 3.24x24 TM3 C => F missense 3.296e-05 4 121374 0 0.66 0.766
drd3_human 101 3.23x23 TM3 I => V missense 8.239e-06 1 121370 0 0.29 0.0
drd3_human 100 3.22x22 TM3 R => P missense 8.24e-06 1 121366 0 0.02 1.0
drd3_human 99 3.21x21 TM3 S => N missense 8.24e-06 1 121360 0 0.05 0.069
drd3_human 93 2.68x67 TM2 G => D missense 8.245e-06 1 121280 0 0.06 1.0
drd3_human 93 2.68x67 TM2 G => S missense 8.245e-06 1 121284 0 0.0 1.0
drd3_human 89 2.64x63 TM2 L => Q missense 8.85e-06 1 113000 0 0.0 0.983 LB (Van der Waals)
drd3_human 80 2.55x55 TM2 T => I missense 8.558e-06 1 116846 0 0.16 0.03
drd3_human 79 2.54x54 TM2 A => G missense 8.529e-06 1 117244 0 0.02 0.364
drd3_human 76 2.51x51 TM2 L => F missense 4.219e-05 5 118500 0 0.0 1.0
drd3_human 68 2.43x43 TM2 V => I missense 1.656e-05 2 120764 0 1.0 0.434
drd3_human 62 2.37x37 TM2 T => N missense 8.264e-06 1 121004 0 0.0 0.999
drd3_human 60 12.50x50 ICL1 L => R missense 8.263e-06 1 121020 0 0.0 1.0
drd3_human 59 12.49x49 ICL1 A => V missense 2.479e-05 3 121018 0 0.01 0.006
drd3_human 58 12.48x48 ICL1 R => Q missense 0.0002148 26 121026 0 0.0 0.368
drd3_human 58 12.48x48 ICL1 R => W missense 1.653e-05 2 121018 0 0.0 0.984
drd3_human 57 1.60x60 TM1 E => K missense 8.262e-06 1 121038 0 0.0 0.999
drd3_human 52 1.55x55 TM1 M => I missense 8.265e-06 1 120994 0 0.12 0.0
drd3_human 52 1.55x55 TM1 M => T missense 0.0002975 36 120998 0 0.0 0.014
drd3_human 46 1.49x49 TM1 G => S missense 8.281e-06 1 120754 0 0.0 1.0
drd3_human 44 1.47x47 TM1 V => I missense 2.488e-05 3 120594 0 0.21 0.003
drd3_human 43 1.46x46 TM1 I => M missense 8.301e-06 1 120464 0 0.0 1.0
drd3_human 38 1.41x41 TM1 A => V missense 4.196e-05 5 119150 0 0.08 0.001
drd3_human 38 1.41x41 TM1 A => T missense 0.0008824 105 118992 2 0.05 0.001
drd3_human 35 1.38x38 TM1 S => F missense 8.562e-06 1 116794 0 0.17 0.004
drd3_human 30 1.33x33 TM1 A => G missense 9.3e-06 1 107532 0 0.03 0.128
drd3_human 29 1.32x32 TM1 H => L missense 9.409e-06 1 106280 0 0.04 0.012
drd3_human 27 1.30x30 TM1 R => H missense 1.967e-05 2 101662 0 0.6 0.003
drd3_human 27 1.30x30 TM1 R => C missense 1.018e-05 1 98258 0 0.07 0.655
drd3_human 26 1.29x29 TM1 A => D missense 5.112e-05 5 97812 0 0.62 0.12
drd3_human 26 1.29x29 TM1 A => T missense 1.025e-05 1 97598 0 0.55 0.003
drd3_human 21 N-term T => I missense 1.142e-05 1 87552 0 0.0 0.965
drd3_human 18 N-term E => D missense 8.458e-05 7 82766 1 0.5 0.005
drd3_human 17 N-term A => V missense 1.296e-05 1 77132 0 0.07 0.013
drd3_human 16 N-term G => E missense 1.324e-05 1 75520 0 0.08 0.008
drd3_human 14 N-term T => I missense 2.757e-05 2 72552 0 0.0 0.895
drd3_human 6 N-term Q => H missense 2.384e-05 1 41952 0 nan 0.003
drd3_human 2 N-term A => T missense 2.75e-05 1 36362 0 nan 0.028


Residue

Diagrams

ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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